-
Pickering emulsions for cancer: Formulation strategies, functional enhancements, and translational considerations
- Back
Metadata
Document Title
Pickering emulsions for cancer: Formulation strategies, functional enhancements, and translational considerations
Name from Authors Collection
Affiliations
Colloids and Polymers Group, Department of Chemical Engineering, School of Engineering, Monash University Malaysia, Jalan Lagoon Selatan, Selangor, Bandar Sunway, 47500, Malaysia; National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, 12120, Thailand; Center of Excellence in Particle and Materials Processing Technology, Department of Chemical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, 10330, Thailand; Bio-Circular-Green Economy Technology & Engineering Center, BCGeTEC, Faculty of Engineering, Chulalongkorn University, Bangkok, 10330, Thailand; Sunway Biofunctional Molecules Discovery Centre (SBMDC), School of Medical and Life Sciences, Sunway University, 5, Jalan Universiti, Bandar Sunway, Selangor, Petaling Jaya, 47500, Malaysia; College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China; Bioresource Processing Research Institute of Australia (BioPRIA), Department of Chemical and Biological Engineering, Monash University, Clayton, 3800, VIC, Australia; Department of Chemical and Biological Engineering, Monash University, Clayton, 3800, VIC, Australia; School of Pharmacy, Monash University Malaysia, Selangor Darul Ehsan, Bandar Sunway, 47500, Malaysia
Type
Review
Source Title
International Journal of Pharmaceutics
ISSN
3785173
Year
2025
Volume
681
Open Access
All Open Access; Hybrid Gold Open Access
Publisher
Elsevier B.V.
DOI
10.1016/j.ijpharm.2025.125873
Abstract
Pickering emulsions (PEs) is a class of emulsions stabilized by solid particles instead of traditional surfactants. Among various applications, PEs have emerged as a promising drug delivery carrier for multiple diseases, including cancer. Through the encapsulation of drug molecules within the dispersed phase or within the interfacial layer, PEs serve as protective shells for pharmaceutical agents during systemic circulations, ensuring enhanced bioavailability. The formulation of PEs is largely centered around designing the emulsion stabilizer, within which stimuli-responsiveness and targeting functionalities can be installed for precise and controlled cancer delivery. This review delves into the considerations for formulating PEs, encompassing the crucial physicochemical properties used to judge emulsion quality and a practical guide to choosing appropriate Pickering stabilizers for oncological applications. We also highlighted recent advancements in using PEs for cancer diagnostics and treatment, focusing on methods, mechanisms, and hurdles to bringing this technology from bench to bedside. © 2025 The Author(s)
Keyword
cancer | Drug delivery | Pickering emulsion | Stimuli-responsive | Targeted therapy | Tumour microenvironment
License
CC BY
Rights
Authors
Publication Source
Scopus
Publication Source
Scopus