• ent-Clavilactone J and Its Quinone Derivative Meroterpenoids from the Fungus Resupinatus sp.

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Metadata

Document Title

ent-Clavilactone J and Its Quinone Derivative Meroterpenoids from the Fungus Resupinatus sp.

Author

Harms K. Paomephan P. Boonpratuang T. Choeyklin R. Boonchird C. Surup F.

Affiliations

Department Microbial Drugs Helmholtz Centre for Infection Research and German Centre for Infection Research (DZIF) Partner Site Hannover-Braunschweig Inhoffenstrasse 7 Braunschweig 38124 Germany; Department of Biotechnology Faculty of Science Mahidol University 272 Thanon 4 Rama VI Bangkok 10400 Thailand; National Biobank of Thailand (NBT) National Science and Technology Development Agency (NSTDA) 144 Thailand Science Park Phahonyothin Road Pathum Thani Khlong Luang 12120 Thailand; Biodiversity-Based Economy Development Office (Public Organization) The Government Complex Commemorating His Majesty the King抯 80th Birthday Anniversary 5 December 2007 Ratthaprasasanabhakdi Building ninth Floor Chaengwattana Road Thung Song Hong Bangkok Lak Si 10210 Thailand; Institute of Microbiology Technische Universit?t Braunschweig Spielmannstra?e 7 Braunschweig 38106 Germany

Type

Article

Source Title

Journal of Natural Products

ISSN

1633864

Year

2023

Volume

86

Issue

11

Page

2580-2584

Open Access

All Open Access Hybrid Gold Green

Publisher

American Chemical Society

DOI

10.1021/acs.jnatprod.3c00174

Abstract

Metabolites 1 and 2 isolated from cultures of the basidiomycete Resupinatus sp. BCC84615 collected in a tropical forest in northeastern Thailand showed weak antibiotic activity against Bacillus subtilis and Staphylococcus aureus and cytotoxicity against cancer cell lines. Their planar structures were elucidated by high-resolution electrospray ionization mass spectrometry and NMR spectroscopy as clavilactone J known from the basidiomycete Ampulloclitocybe clavipes and its new 1 4-benzoquinone derivative. A detailed analysis of the ROESY correlations in 1 confirmed the recent revision of the relative configuration of clavilactone J. However specific rotation and Cotton effects observed by electronic circular dichroism were contrary to those of the clavilactones; thus we assigned a rare antipodal absolute configuration. ? 2023 The Authors. Published by American Chemical Society and American Society of Pharmacognosy.

License

CC BY

Rights

Authors

Publication Source

WOS

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