• Talarostatin a vermistatin derivative from the soil-derived fungus Talaromyces thailandensis PSU-SPSF059

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Document Title

Talarostatin a vermistatin derivative from the soil-derived fungus Talaromyces thailandensis PSU-SPSF059

Author

Ningsih B.N.S. Rukachaisirikul V. Phongpaichit S. Muanprasat C. Preedanon S. Sakayaroj J. Intayot R. Jungsuttiwong S.

Affiliations

Division of Physical Science and Center of Excellence for Innovation in Chemistry Faculty of Science Prince of Songkla University Songkhla Thailand; Department of Chemistry Faculty of Mathematics and Natural Science University of Mataram Mataram West Nusa Tenggara Indonesia; Division of Biological Science Faculty of Science Prince of Songkla University Songkhla Thailand; Chakri Naruebodindra Medical Institute Faculty of Medicine Ramathibodi Hospital Mahidol University Samut Prakarn Thailand; National Biobank of Thailand (NBT) National Science and Technology for Development Agency (NSTDA) Klong Luang Pathum Thani Thailand; School of Science Walailak University Nakhonsithammarat Thasala Thailand; Department of Chemistry and Center of Excellence for Innovation in Chemistry Faculty of Science Ubon Ratchathani University Ubon Ratchathani Thailand

Type

Article

Source Title

Natural Product Research

ISSN

14786419

Year

2023

Open Access

All Open Access Green

Publisher

Taylor and Francis Ltd.

DOI

10.1080/14786419.2023.2188209

Abstract

The soil-derived fungus Talaromyces thailandensis PSU-SPSF059 produced one new vermistatin derivative talarostatin and seven known compounds including two vermistatins two chrodrimanins two diphenyl ethers and one penicillide derivative. Extensive spectroscopic analysis was performed to identify their structures. The absolute configuration of talarostatin was determined by comparing the experimental and calculated electronic circular dichroism data. The antimicrobial and cytotoxic activities of the isolated secondary metabolites were also evaluated. ? 2023 Informa UK Limited trading as Taylor & Francis Group.

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Rights

Informa UK Limited

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