Chiang Mai University; Chiang Mai University; Chiang Mai University; University of Wollongong; University of Wollongong; National Science & Technology Development Agency - Thailand; National Center Genetic Engineering & Biotechnology (BIOTEC); Queensland University of Technology (QUT); Chiang Mai University
Type
Article
Source Title
TETRAHEDRON
Year
2019
Volume
75
Issue
15
Page
2336-2342
Open Access
Green Submitted
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI
10.1016/j.tet.2019.03.004
Format
PDF
Abstract
The phytochemical investigation of the leaf extract of Uvaria cherrevensis (Annonaceae) yielded three new cyclohexene (9Z)-octadec-9-enyl ethers, cherrevenols M-O (1-3), and a known fatty ester derivative (4). The structures of the isolated compounds were elucidated by spectroscopic and computer-aided molecular modelling methods. Ozone Induced Dissociation (OzID) mass spectrometry was employed to determine the C-9 position of the side chain olefinic double bonds, while C-13 NMR spectroscopy indicated their (Z)-configurations. All isolated compounds were evaluated for their antimalarial and cytotoxic activities; all were inactive. Crown Copyright (C) 2019 Published by Elsevier Ltd. All rights reserved.
Thailand Research Fund; Office of the Higher Education Commission [MRG6180098]; Center of Excellence for Innovation in Chemistry (PERCH-CIC); Chiang Mai University; University of Wollongong; Science Achievement Scholarship of Thailand (SAST); UOW School of Medicine; Australian Government
