Prince of Songkla University; Prince of Songkla University; Prince of Songkla University; National Science & Technology Development Agency - Thailand; Walailak University
Type
Article
Source Title
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
ISSN
1860-5397
Year
2022
Volume
18
Page
479-485
Open Access
gold, Green Published
Publisher
BEILSTEIN-INSTITUT
DOI
10.3762/bjoc.18.50
Format
PDF
Abstract
Two new sesquiterpenes, trichocitrinovirenes A (1) and B (2), and five known compounds including four structurally related sesquiterpenes and one gamma-lactone were isolated from the soil-derived fungus Trichoderma citrinoviride PSU-SPSF346. The structures were identified by analysis of their spectroscopic data. The relative configuration was assigned based on NOEDIFF data. The absolute configuration of compound 1 was established according to specific rotations and ECD data while that of compound 2 was proposed based on biosynthetic considerations. Compound 2 possesses a rare bicyclic sesquiterpene skeleton. The antimicrobial and cytotoxic activities of the isolated compounds were evaluated.
