• Selenium-Substituted BOIMPY for Enhanced Photodynamic Therapy

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Metadata

Document Title

Selenium-Substituted BOIMPY for Enhanced Photodynamic Therapy

Name from Authors Collection

Tharamak S.

|

Ouengwanarat B.

|

Khrootkaew T.

|

Muangsopa P.

|

Chansaenpak K.

|

Khotchasanthong K.

|

Chainok K.

Scopus Author ID

36620885100

ORCID ID

NULL

|

Burgess K.

|

Kamkaew A.

Scopus Author ID

26039254300

ORCID ID

NULL

Affiliations

School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand; Department of Chemistry, Center of Excellence for Innovation in Chemistry, Special Research Unit for Advanced Magnetic Resonance, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand; National Nanotechnology Center, National Science and Technology Development Agency, Thailand Science Park, Pathum Thani, 12120, Thailand; Thammasat University Research Unit in Multifunctional Crystalline Materials and Applications (TU-McMa), Faculty of Science and Technology, Thammasat University, Pathum Thani, 12121, Thailand; Department of Chemistry, Texas A&M University, College Station, 77842-3012, TX, United States

Source Title

ACS Medicinal Chemistry Letters

ISSN

19485875

Year

2025

Volume

16

Issue

7

Page

1202-1208

Open Access

All Open Access; Green Open Access; Hybrid Gold Open Access

Publisher

American Chemical Society

DOI

10.1021/acsmedchemlett.5c00174

Abstract

Seleno-substituted bis-(boron difluoride)-8-imidazodipyrromethene (BOIMPY) derivatives displayed improved photophysical features over twisted-BOIMPY, such as greater Stokes shifts, while compromising radiative relaxation and intersystem crossing, making them suitable for imaging-guided photodynamic therapy (PDT). One exhibited improved Type I and Type II PDT against cancer cells when activated by near-infrared light. Its potential as a targeted PDT agent for cancer treatment is demonstrated by its remarkable phototoxicity in the nanomolar range and minimal dark toxicity. © 2025 The Authors. Published by American Chemical Society.

License

CC BY-NC-ND

Rights

Authors

Publication Source

Scopus

Publication Source

Scopus

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