National Science & Technology Development Agency - Thailand; National Center Genetic Engineering & Biotechnology (BIOTEC); Walailak University; Hiroshima University; Mahidol University; Mahidol University
Type
Article
Source Title
NATURAL PRODUCT RESEARCH
Year
2021
Volume
35
Issue
21
Page
3556-3561
Open Access
Green Submitted
Publisher
TAYLOR & FRANCIS LTD
DOI
10.1080/14786419.2020.1713119
Format
PDF
Abstract
Five new compounds, iranginins A-E (1-5), together with sixteen known compounds were isolated from the insect pathogenic fungus Ophiocordyceps irangiensis BCC 2728. The structures and the absolute configurations of the new compounds were established by spectroscopic analyses, the application of modified Mosher's method (for 2), ECD calculation (for 5), and X-ray crystallographic analysis (for 4). LL-Z1640-5 and mucorisocoumarin C were active against Mycobacterium tuberculosis (MIC 41.7 and 85.0 mu M, respectively), while peyroisocoumarin D exhibited cytotoxic activity (IC50 65.6 mu M).
National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Thailand; Functional Materials and Nanotechnology Centre of Excellence, Walailak University through the National Science Technology and Innovation Policy Office for Integrated Research and Innovation Plan [256113A3050001]
