National Science & Technology Development Agency - Thailand; National Center Genetic Engineering & Biotechnology (BIOTEC)
Type
Article
Source Title
RSC ADVANCES
Year
2021
Volume
11
Issue
9
Open Access
Green Published, gold
Publisher
ROYAL SOC CHEMISTRY
DOI
10.1039/d1ra06963b
Format
PDF
Abstract
Decagram scale synthesis of favipiravir was performed in 9 steps using diethyl malonate as cheap starting material. Hydrogenation and bromination steps were achieved by employing a continuous flow reactor. The synthetic process provided a total of 16% yield and it is suitable for larger-scale synthesis and production.
National Center For Genetic Engineering and Biotechnology (BIOTEC) [P2050576, P2050882]; Government Pharmaceutical Organization (GPO) [P2050576, P2050882]
