Mahidol University; Khon Kaen University; Khon Kaen University; National Science & Technology Development Agency - Thailand; National Metal & Materials Technology Center (MTEC)
Type
Article
Source Title
CELL ADHESION & MIGRATION
ISSN
1933-6918
Year
2021
Volume
15
Issue
1
Page
152-165
Open Access
gold, Green Published
Publisher
TAYLOR & FRANCIS INC
DOI
10.1080/19336918.2021.1924422
Format
PDF
Abstract
Extensive desmoplasia in cholangiocarcinoma (CCA) is associated with tumor aggressiveness, indicating a need for further understanding of CCA cell-matrix interaction. This study demonstrated laminin as the most potent attractant for CCA cell migration and the vast elevation of its receptor integrin beta 4 (ITGB4) in CCA cell lines. Besides, their high expressions in CCA tissues were correlated with lymphatic invasion and the presence of ITGB4 was also associated with short survival time. ITGB4 silencing revealed it as the receptor for laminin-induced HuCCA-1 migration, but KKU-213 utilized 37/67-kDa laminin receptor (LAMR) instead. These findings highlight the role of ITGB4 and LAMR in transducing laminin induction of CCA cell migration and the potential of ITGB4 as diagnostic and prognostic biomarkers for CCA.
