Texas A&M University System; Texas A&M University College Station; University of North Carolina; University of North Carolina Chapel Hill; National Science & Technology Development Agency - Thailand; National Nanotechnology Center (NANOTEC)
Type
Article
Source Title
CHEMICAL COMMUNICATIONS
Year
2017
Volume
53
Issue
62
Page
8657-8659
Open Access
Green Accepted
Publisher
ROYAL SOC CHEMISTRY
DOI
10.1039/c7cc04402j
Format
PDF
Abstract
The radiofluorination of N-heterocyclic carbene (NHC) phosphorus(V) fluoride adducts has been investigated. The results show that the IMe-PF5 derivative (IMe = 1,3-dimethylimidazol-2-ylidene) undergoes a Lewis acid promoted F-18-F-19 isotopic exchange. The resulting radiofluorinated probe is remarkably resistant to hydrolysis both in vitro as well as in vivo.
Funding Sponsor
Cancer Prevention Research Institute of Texas [RP130604]; Texas A&M University (Arthur E. Martell Chair of Chemistry); National Cancer Institute [P30-CA016086-35-37]; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill; NATIONAL CANCER INSTITUTE [P30CA016086] Funding Source: NIH RePORTER
