National Science & Technology Development Agency - Thailand; National Center Genetic Engineering & Biotechnology (BIOTEC)
Type
Article
Source Title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN
0066-4804
Year
2002
Volume
46
Open Access
Green Published
Publisher
AMER SOC MICROBIOLOGY
DOI
10.1128/AAC.46.4.1112-1113.2002
Format
PDF
Abstract
Bioassay-guided fractionation of the extract from the fermentation broth of Streptomyces spectabilis BCC 4785 led to the isolation of three principle antimalarial agents, metacycloprodigiosin, bafilomycin A, and spectinabilin. Metacycloprodigiosin exhibited potent in vitro activity against Plasmodium falciparum K1, with a 50% inhibitory concentration of 0.0050 +/- 0.0010 mug/ml, while its cytotoxicity was much weaker.
