Abstract
Four undescribed polyoxygenated compounds including aspergilosidic acid aspergilosidols A B and aspergilosidone along with seven known compounds were isolated from the endophytic fungus Aspergillus aculeatus BCC69431. The chemical structures with their absolute stereochemistry were determined by NMR spectroscopic information CD spectral data and chemical reaction. The isolated compounds were evaluated for biological activities such as antimalarial antimycobacterial antibacterial anti-plant pathogenic fungal activities as well as cytotoxicity against cancerous (MCF-7 and NCI朒187) and non-cancerous (Vero) cells. Only violaceoid A (8) exhibited antimalarial against Plasmodium falciparum K1 strain (IC50 9.62 ?M) antibacterial against Staphylococcus aureus (MIC 12.50 ?g/mL) and antifungal against Colletotrichum acutatum (MIC 50.0 ?g/mL) activities without significant cytotoxicity. In addition himeic acid G (11) showed anti-Mycobacterium tuberculosis activity with MIC value of 25.0 ?g/mL with no cytotoxicity at the maximum tested concentration (50 ?g/mL) while microsphaerone C (9) possessed cytotoxicity against NCI朒187 with IC50 value of 1.88 ?M. ? 2023 Elsevier Ltd
