• Neutralizing antibodies against Omicron BA.5 among children with infection alone, vaccination alone, and hybrid immunity

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22/09/2023 by   

Metadata

Document Title

Neutralizing antibodies against Omicron BA.5 among children with infection alone, vaccination alone, and hybrid immunity

Author

Suntronwong N., Kanokudom S., Assawakosri S., Vichaiwattana P., Klinfueng S., Phowatthanasathian H., Chansaenroj J., Srimuan D., Thatsanathorn T., Duangchinda T., Chantima W., Pakchotanon P., Sudhinaraset N., Wanlapakorn N., Poovorawan Y.

Affiliations

Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand; Center of Excellence in Osteoarthritis and Musculoskeleton, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, 10330, Thailand; Chulalongkorn University International Medical Program (CU-MEDi), Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand; Molecular Biology of Dengue and Flaviviruses Research Team, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, 12120, Thailand; Division of Dengue Hemorrhagic Fever Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand; Siriraj Center of Research Excellence in Dengue and Emerging Pathogens, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand; The Royal Society of Thailand (FRS(T)), Sanam Sueapa, Dusit, Bangkok, 10330, Thailand

Type

Article

Source Title

International Journal of Infectious Diseases

ISSN

12019712

Year

2023

Volume

134

Page

18-22

Open Access

All Open Access, Gold

Publisher

Elsevier B.V.

DOI

10.1016/j.ijid.2023.05.005

Format

PDF

Abstract

Objectives: To assess the binding antibody response and strength of neutralization against Omicron BA.5 in serum samples from children with different antigen exposures (infection/vaccination) and hybrid immunity. Methods: This study recruited children aged 5-7 years. All samples were tested for anti-nucleocapsid immunoglobulin (Ig)G, anti-receptor binding domain (RBD) IgG, and total anti-RBD Ig. Neutralizing antibodies (nAbs) against Omicron BA.5 were determined using a focus reduction neutralization test. Results: A total of 196 serum samples from unvaccinated children with infection (n = 57), vaccination alone (n = 71), and hybrid immunity (n = 68). Our results showed that 90% of the samples from children with hybrid immunity, 62.2% from two-dose vaccination, and 48% from Omicron infection alone had detectable nAbs against Omicron BA.5. The highest neutralizing titer was observed in infection plus two-dose vaccination, which reached 6.3-fold increase, whereas nAb titers in two-dose vaccination was comparable to Omicron-infected sera. However, sera from pre-Omicron infection and single-dose vaccination failed to neutralize Omicron BA.5; although, the total anti-RBD Ig were comparable with Omicron-infected sera. Conclusion: This result highlights that hybrid immunity provided cross-reactive antibodies to neutralize Omicron BA.5 compared with either vaccination or infection alone. The finding emphasizes the importance of vaccination in unvaccinated children who are infected with pre-Omicron or Omicron variants. ? 2023 The Author(s)

License

CC BY-NC-ND

Rights

Authors

Publication Source

WOS

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