• Molecular Docking of Bioactive Compounds from Thai Medicinal Plants Against Xanthine Oxidase for Gout Treatment

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06/12/2024 by   

Metadata

Document Title

Molecular Docking of Bioactive Compounds from Thai Medicinal Plants Against Xanthine Oxidase for Gout Treatment

Author

Pothipongsa A., Damsud T., Burut-Archanai S.

Affiliations

UCIBIO, Department of Life Sciences, Nova School of Science and Technology, Caparica, 2829-516, Portugal; Associate Laboratory i4HB, Nova School of Science and Technology, Caparica, 2829-516, Portugal; Biodiversity Research Center, Academia Sinica, Taipei, 11529, Taiwan; Department of Microbiology Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand; Biodiversity Center Kasetsart University, Bangkok, 10900, Thailand; Microbial Diversity and Utilization Research Team, Thailand Bioresource Research Center, National Centre for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology, Development Agency (NSTDA), Pathum Thani, 12120, Thailand; Department of Food Science, University of Copenhagen, Frederiksberg C, 1958, Denmark; Departamento de Microbiologia, ICB, C.P. 486, Universidade Federal de Minas Gerais, MG, Belo Horizonte, 31270-901, Brazil; Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, United States; Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN 37235, United States; Laboratory of Genetics, DOE Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, Center for Genomic Science Innovation, J.F. Crow Institute for the Study of Evolution, University of Wisconsin-Madison, Madison, WI 53726, United States

Type

Article

Source Title

iScience

ISSN

25890042

Year

2024

Volume

27

Issue

2

Open Access

All Open Access, Gold

Publisher

Elsevier Inc.

DOI

10.1016/j.isci.2024.108987

Abstract

When Saccharomyces cerevisiae grows on mixtures of glucose and galactose, galactose utilization is repressed by glucose, and induction of the GAL gene network only occurs when glucose is exhausted. Contrary to reference GAL alleles, alternative alleles support faster growth on galactose, thus enabling distinct galactose utilization strategies maintained by balancing selection. Here, we report on new wild populations of Saccharomyces cerevisiae harboring alternative GAL versions and, for the first time, of Saccharomyces paradoxus alternative alleles. We also show that the non-functional GAL version found earlier in Saccharomyces kudriavzevii is phylogenetically related to the alternative versions, which constitutes a case of trans-specific maintenance of highly divergent alleles. Strains harboring the different GAL network variants show different levels of alleviation of glucose repression and growth proficiency on galactose. We propose that domestication involved specialization toward thriving in milk from a generalist ancestor partially adapted to galactose consumption in the plant niche. ? 2024 The Authors

License

CC BY

Rights

Authors

Publication Source

WoS

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