• Lanostane–Meroterpene Conjugates with Unusual Aryl Ether Linkage and a Lanostane Dimer from Artificially Cultivated Fruiting Bodies of Ganoderma cf. hochiminhense

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Metadata

Document Title

Lanostane–Meroterpene Conjugates with Unusual Aryl Ether Linkage and a Lanostane Dimer from Artificially Cultivated Fruiting Bodies of Ganoderma cf. hochiminhense

Author

Sappan M.

Name from Authors Collection

Chinthanom P.

|

Srichomthong K.

|

Thummarukcharoen T.

Scopus Author ID

57189992277

|

Choeyklin R.

|

Sangdee A.

|

Isaka M.

Affiliations

National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathumthani, 12120, Thailand; National Biobank of Thailand, National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathumthani, 12120, Thailand; Department of Biology, Faculty of Science, Mahasarakham University, Khamriang, Kantarawichai, Maha Sarakham, 44150, Thailand

Type

Article

Source Title

ACS Omega

ISSN

24701343

Year

2025

Volume

10

Issue

41

Page

48818-48828

Open Access

All Open Access; Gold Open Access; Green Open Access

Publisher

American Chemical Society

DOI

10.1021/acsomega.5c06826

Abstract

Ten previously undescribed compounds, including eight lanostane–meroterpene conjugates, ganohochimins A–H (1–8), a lanostane dimer, ganohochimate A (9), and a meroterpenoid, fornicin F (10), were isolated from the cultivated mushroom Ganoderma cf. hochiminhense(strain TBRC-BCC 22084). The 24S-configuration of ganohochimin A (1) was determined by cleavage of the aryl ether under acidic conditions. The structure of ganohochimate A (9) was confirmed by alkaline hydrolysis to cleave into two lanostane units. Ganohochimins exhibited cytotoxicity against NCI-H187 (small-cell lung cancer) cells (IC507.7–33 μM) and noncancerous Vero cells (IC506.3–30 μM). © 2025 The Authors. Published by American Chemical Society

License

CC BY

Rights

Authors

Publication Source

Scopus

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