National Science & Technology Development Agency - Thailand; National Center Genetic Engineering & Biotechnology (BIOTEC)
Type
Article
Source Title
JOURNAL OF ANTIBIOTICS
ISSN
0021-8820
Year
2004
Volume
57
Issue
7
Open Access
Bronze
Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI
10.7164/antibiotics.57.732
Format
PDF
Abstract
Optimal fermentation conditions for enniatin production using the entomopathogenic fungus Verticillium hemipterigenum BCC 1449 have been investigated. Among various liquid media tested, highest efficiency of enniatin production was achieved by fermentation in yeast extract sucrose. Application of this condition to large-scale fermentation resulted in the isolation of three new analogs, O-1, O-2 and O-3, which are closely related isomers that were characterized as an inseparable mixture, along with seven known enniatins.
