Rajamangala University of Technology; University of California System; University of California Santa Cruz; Suranaree University of Technology; Suranaree University of Technology; National Science & Technology Development Agency - Thailand; National Nanotechnology Center (NANOTEC)
Type
Article
Source Title
MOLECULES
Year
2022
Volume
27
Issue
13
Open Access
gold, Green Published
Publisher
MDPI
DOI
10.3390/molecules27134078
Format
PDF
Abstract
We develop an electrochemical sensor for the determination of bromhexine hydrochloride (BHC), a widely use mucolytic drug. The sensor is prepared by electrodeposition of cobalt oxides (CoOx) on a glassy carbon electrode modified with carboxylated single-walled carbon nanotubes (SWCNT). A synergistic effect between CoOx and SWCNT is observed, leading to a significant improvement in the BHC electrooxidation current. Based on cyclic voltammetry studies at varying scan rates, we conclude that the electrochemical oxidation of BHC is under mixed diffusion-adsorption control. The proposed sensor allows the amperometric determination of BHC in a linear range of 10-500 mu M with a low applied voltage of 0.75 V. The designed sensor provides reproducible measurements, is not affected by common interfering substances, and shows excellent performance for the analysis of BHC in pharmaceutical preparations.
Suranaree University of Technology (SUT), Thailand Science Research and Innovation (TSRI); National Science, Research and Innovation Fund (NSRF) [42851, 90464]
