Dengue virus susceptibility in Aedes aegypti linked to natural cytochrome P450 promoter variants Back 02/07/2026 by stks-intrenship Metadata Share Document TitleDengue virus susceptibility in Aedes aegypti linked to natural cytochrome P450 promoter variantsName from Authors Collection Merkling S.H. | Couderc E. | Crist A.B. | Dabo S. | Daron J. | Jupatanakul N. | Burckbuchler M. | Vial T. | Sismeiro O. | Legendre R. | Pain A. | Varet H. | Jiolle D. | Ayala D. | Paupy C. | Marois E. | Lambrechts L. AffiliationsInstitut Pasteur, Université Paris Cité, CNRS UMR2000, Insect-Virus Interactions Unit, Paris, France; Sorbonne Université, Collège Doctoral, Paris, France; National Center for Genetic Engineering and Biotechnology (BIOTEC), Pathum Thani, Khlong Luang District, Thailand; Université de Strasbourg, CNRS UPR9022, INSERM U1257, Strasbourg, France; Institut Pasteur, Digital Education Division, Education Department, Paris, France; Institut Pasteur, Université Paris Cité, Bioinformatics and Biostatistics Hub, Paris, France; MIVEGEC, Montpellier University, IRD, CNRS, Montpellier, France; Centre Interdisciplinaire de Recherches Médicales de Franceville, Franceville, GabonTypeArticleSource TitleNature CommunicationsISSN20411723Year2025Issue1Open AccessAll Open Access; Gold Open Access; Green Open AccessPublisherNature ResearchDOI10.1038/s41467-025-62693-yAbstractThe mosquito Aedes aegypti is the primary vector for dengue virus (DENV), which infects millions of people annually. Variability in DENV susceptibility among wild Ae. aegypti populations is governed by genetic factors, but specific causal variants are unknown. Here, we identify a cytochrome P450-encoding gene (CYP4G15) whose genetic variants drive differences in DENV susceptibility in a natural Ae. aegypti population. CYP4G15 is transiently upregulated in DENV-resistant midguts, while knockdown increases susceptibility, and transgenic overexpression enhances resistance. A naturally occurring 18-base-pair promoter deletion reduces CYP4G15 expression and confers higher DENV susceptibility. The unexpected role of a cytochrome P450 in DENV susceptibility challenges the long-standing focus on canonical immune pathways and opens new avenues for understanding antiviral defense and DENV transmission in mosquitoes. © The Author(s) 2025.Knowledge Taxonomy Level 1Biological SciencesKnowledge Taxonomy Level 2MicrobiologyKnowledge Taxonomy Level 3Applied microbiologyLicenseCC BYRightsAuthorsLinkhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-105013122891&doi=10.1038%2Fs41467-025-62693-y&partnerID=40&md5=cc0aa1aadb45f52efdebd83e5614893fPublication SourceScopusPublication SourceScopus Continue browsing Preparation and Physicochemical Properties of a New Biolubricant from Epoxidized Fatty Acids and Diethylene Glycol Monomethyl Ether Multi-Experiment and Multi-Locus Genome-Wide Association Mapping for Grain Arsenic in Rice Population Back to items list
