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Cytokine and chemokine kinetics in natural human dengue infection as predictors of disease outcome
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Metadata
Document Title
Cytokine and chemokine kinetics in natural human dengue infection as predictors of disease outcome
Name from Authors Collection
Affiliations
Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand; Department of Clinical Pathology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand; Integrative Computational BioScience (ICBS) Center, Mahidol University, Nakhon Pathom, 73170, Thailand; Single-Cell Omics and Systems Biology of Diseases Research Unit, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand; Division of Medical Bioinformatics, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand; Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand; Siriraj Genomics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand; Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand; School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand; Ecology and Emergence of Arthropod-borne Pathogens Unit, Institut Pasteur, Paris, France; Centre National de La Recherche Scientifique (CNRS), URM2000, Paris, France; Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Endocrinology Division, Department of Medicine, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand; Thasongyang Hospital, Tak, Thailand; Mahidol Vivax research unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Armed Forces Research Institute of Medical Science, Bangkok, Thailand; Molecular Biology of Dengue and Flaviviruses Research Team, National Center for Genetic Engineering and Biotechnology, National Science and Development Agency, Pathum Thani, Thailand; Division of Dengue Hemorrhagic Fever Research, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Faculty of Medicine, King Mongkut’s Institute of Technology Ladkrabang, Bangkok, Thailand
Type
Article
Source Title
Scientific Reports
ISSN
20452322
Year
2025
Issue
1
Open Access
All Open Access; Gold Open Access; Green Open Access
Publisher
Nature Research
DOI
10.1038/s41598-025-99628-y
Abstract
Dengue is an important tropical disease with considerable global impact. Despite this, there remains an urgent need for reliable biomarkers to predict disease severity, as well as effective antiviral drugs and targeted treatments. In this study, we conducted a comprehensive profiling of 41 plasma mediators in patients with asymptomatic dengue (AD) and symptomatic dengue (SD), which includes mild dengue fever (DF) and severe dengue hemorrhagic fever (DHF). Our findings revealed that the levels of nearly all measured mediators were consistently lower in AD compared to SD patients, suggesting a potential protective cytokine response signature. Time-course cytokine analysis in SD shown significantly elevated levels of pro-inflammatory cytokines and chemokines associated with inflammation and viral clearance upon the acute phase, while various growth factors were elevated during the convalescence. Notably, we identified elevated IL-15 levels in DHF patients three days before fever subsidence, highlighting its potential as an early prognostic biomarker for severe disease outcomes. Furthermore, prolonged high levels of IL-8 and IP-10 in DHF during the critical period may contribute to dengue immunopathogenesis. This study advances the understanding of cytokine dynamics in the natural course of human dengue infection, providing valuable insights for the development of targeted treatments and prognostic biomarkers. © The Author(s) 2025.
Keyword
Manihot esculenta | Plant defense mechanisms | Stem puncture inoculation | Xanthomonas axonopodis pv. manihotis
Knowledge Taxonomy Level 1
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Knowledge Taxonomy Level 3
License
CC BY-NC-ND
Rights
Authors
Publication Source
Scopus
Publication Source
Scopus