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Chitosan-based intelligent theragnosis nanocomposites enable pH-sensitive drug release with MR-guided imaging for cancer therapy
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Metadata
Document Title
Chitosan-based intelligent theragnosis nanocomposites enable pH-sensitive drug release with MR-guided imaging for cancer therapy
Author
Lim E.-K.,Sajomsang W.,Choi Y.,Jang E.,Lee H.,Kang B.,Kim E.,Haam S.,Suh J.-S.,Chung S.J.,Huh Y.-M.
Name from Authors Collection
Affiliations
Department of Radiology, College of Medicine, Yonsei University, Seoul 120-752, South Korea; YUHS-KRIBB Medical Convergence Research Institute, Seoul 120-752, South Korea; Nanodelivery System Laboratory (NDS), National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Thailand Science Park, Pathumthani 12120, Thailand; BioNanotechnology Research Center, KRIBB, Yuseong, Daejeon 305-806, South Korea; Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, South Korea; Department of Chemistry, Dongguk University, Seoul 100-715, South Korea
Type
Article
Source Title
Nanoscale Research Letters
ISSN
19317573
Year
2013
Volume
8
Issue
1
Page
1-12
Open Access
All Open Access, Gold, Green
Publisher
Springer New York LLC
DOI
10.1186/1556-276X-8-467
Abstract
Smart drug delivery systems that are triggered by environmental conditions have been developed to enhance cancer therapeutic efficacy while limiting unwanted effects. Because cancer exhibits abnormally high local acidities compared to normal tissues (pH 7.4) due to Warburg effects, pH-sensitive systems have been researched for effective cancer therapy. Chitosan-based intelligent theragnosis nanocomposites, N-naphthyl-O-dimethymaleoyl chitosan-based drug-loaded magnetic nanoparticles (NChitosan-DMNPs), were developed in this study. NChitosan-DMNPs are capable of pH-sensitive drug release with MR-guided images because doxorubicin (DOX) and magnetic nanocrystals (MNCs) are encapsulated into the designed N-naphthyl-O-dimethymaleoyl chitosan (N-nap-O-MalCS). This system exhibits rapid DOX release as acidity increases, high stability under high pH conditions, and sufficient capacity for diagnosing and monitoring therapeutic responses. These results demonstrate that NChitosan-DMNPs have potential as theragnosis nanocomposites for effective cancer therapy. © 2013 Lim et al.; licensee Springer.
Industrial Classification
Knowledge Taxonomy Level 1
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Knowledge Taxonomy Level 3
License
CC BY
Rights
Author
Publication Source
Scopus