• Cannabidiol and Aza-BODIPY Coencapsulation for Photodynamic Therapy Enhancement in Liver Cancer Cells

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06/12/2024 by   

Metadata

Document Title

Cannabidiol and Aza-BODIPY Coencapsulation for Photodynamic Therapy Enhancement in Liver Cancer Cells

Author

Kampaengsri S., Muangsopa P., Pangjantuk A., Chansaenpak K., Lai R.-Y., Noisa P., Kamkaew A.

Affiliations

Aquaculture and Aquatic Resource Management (AARM), Department of Food, Agriculture and Bioresources, Asian Institute of Technology, Pathumthani, Klong Luang, 12120, Thailand; Center of Excellence in Wildlife, Exotic and Aquatic Animal Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, 10330, Thailand; Integrative Aquaculture Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathumtani, Klong Luang, 12120, Thailand; Department of Aquaculture, College of Fisheries, Ratnagiri, 415 629, India; Department of Food Chemistry, Institute of Nutrition, Mahidol University, Salaya, Nakhon Pathom, Phutthamonthon, 73170, Thailand; Moredun Research Institute, Pentlands Science Park, Penicuik, EH26 0PZ, United Kingdom

Type

Article

Source Title

Aquaculture Reports

ISSN

23525134

Year

2024

Volume

35

Open Access

All Open Access, Gold

Publisher

Elsevier B.V.

DOI

10.1016/j.aqrep.2024.101947

Abstract

The aim of this study was to investigate the antimicrobial activity of guava (Psidium guajava) and star gooseberry (Phyllanthus acidus) leaf extracts and their effects as dietary supplements on the growth performance, intestinal (hindgut) microflora composition, immuno-hematological parameters, and disease resistance of Nile tilapia (Oreochromis niloticus) against Aeromonas hydrophila. Three hundred and sixty Nile tilapia (8.9 ? 0.2 g/fish) were randomly distributed into twelve aquaria (30 fish per aquarium) within a recirculation system. The fish were fed diets supplemented with leaf extracts of guava (GLE), star gooseberry (SGLE), or a mixture of GLE and SGLE (MxLE) at 10 g/kg feed for a duration of 12 weeks, after which their growth performance and intestinal microbial composition were determined. A bacterial challenge with A. hydrophila was performed, and the immune-hematological parameters of the fish and their relative percentage survival (RPS) were determined. Results showed that gallic acid, p-coumaric acid, quercetin, and kaempferol were present in the GLE, SGLE, and MxLE extracts. The GLE and MxLE extracts had significantly higher antimicrobial activity against A. hydrophila than the SGLE. Growth and feed utilization were significantly improved in Nile tilapia after dietary supplementation with all the plant extracts. The intestinal microbial composition of the plant extract groups differed significantly and marginally from the control group. Notably, the post-challenge immune and hematological parameters were considerably enhanced. Furthermore, the RPS of tilapia was significantly higher in diets supplemented with GLE, SGLE, and MxLE extracts compared to the control. These results demonstrated that supplementing the tilapia diets with GLE, SGLE, and MxLE extracts could improve their growth and feed utilization, immuno-hematological response, and disease resistance against A. hydrophila. These plant extracts could also change the composition of the intestinal microbiota. Hence, GLE, SGLE, and MxLE extracts appear to be effective prophylactic and antimicrobial agents for use in Nile tilapia aquaculture. ? 2024 The Authors

Industrial Classification

Agriculture | Fishing and Hunting | Forestry

Knowledge Taxonomy Level 1

Biological Sciences

Knowledge Taxonomy Level 3

Marine and freshwater biology

License

CC BY

Rights

Authors

Publication Source

WoS

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