• Association of genetic variation on X chromosome with systemic lupus erythematosus in both Thai and Chinese populations

  • Back
06/12/2024 by   

Metadata

Document Title

Association of genetic variation on X chromosome with systemic lupus erythematosus in both Thai and Chinese populations

Author

Tangtanatakul P., Lei Y., Jaiwan K., Yang W., Boonbangyang M., Kunhapan P., Sodsai P., Mahasirimongkol S., Pisitkun P., Yang Y., Eu-Ahsunthornwattana J., Aekplakorn W., Jinawath N., Neelapaichit N., Hirankarn N., Wang Y.-F.

Affiliations

Department of Immunology, Graduate Program in Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand; Department of Research and Development, Division of Dengue Hemorrhagic Fever Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok-Noi, Bangkok, 10700, Thailand; Nuffield Department of Medicine, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Division of Emerging Infectious Disease, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok-Noi, Bangkok, 10700, Thailand; Pediatric Department, Khon Kaen Hospital, Ministry of Public Health, Khon Kaen, 40000, Thailand; Pediatric Department, Songkhla Hospital, Ministry of Public Health, Songkhla, 90100, Thailand; Molecular Biology of Dengue and Flaviviruses Research Team, Medical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Bangkok, 12120, Thailand; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, United Kingdom; Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand; Department of Medicine, University of Oxford, Oxford, United Kingdom; Department of Medicine, Faculty of Medicine, Imperial College, Hammersmith Campus, LondonW12 0NN, United Kingdom

Type

Article

Source Title

Virus Research

ISSN

1681702

Year

2024

Volume

345

Open Access

All Open Access, Hybrid Gold

Publisher

Elsevier B.V.

DOI

10.1016/j.virusres.2024.199382

Abstract

Natural killer cells (NK cells) are the front line of immune cells to combat pathogens and able to influence the subsequent adaptive immune responses. One of the factors contributing to pathogenesis in dengue hemorrhagic fever (DHF) disease is aberrant immune activation during early phase of infection. This study explored the profile of NK cells in dengue infected pediatric patients with different degrees of disease severity. DHF patients contained higher frequency of activated NK cells but lower ratio of CD56dim:CD56bright NK subsets. Activated NK cells exhibited alterations in several NK receptors. Interestingly, the frequencies of NKp30 expressing activated NK cells were more pronounced in dengue fever (DF) than in DHF pediatric patients. In vitro functional analysis indicated that degranulation of NK cells in responding to dengue infected dendritic cells (DCs) required cell-cell contact and type I IFNs. Meanwhile, Interferon gamma (IFN-?) production initially required cell-cell contact and type I IFNs followed by Interleukin-12 (IL-12), Interleukin-15 (IL-15) and Interleukin-18 (IL-18) resulting in the amplification of IFN-? producing NK cells over time. This study highlighted the complexity and the factors influencing NK cells responses to dengue virus. Degree of activation, phenotypes of activated cells and the crosstalk between NK cells and other immune cells, could modulate the outcome of NK cells function in the dengue disease. ? 2024

License

CC BY-NC-ND

Rights

Authors

Publication Source

WoS

Continue browsing