Abstract
The structure of a constrained bicyclic chiral derivatizing agent (CDA),1,2,3,4-tetrahydro-1,4-epoxynaphthalene-1-carboxylic acid, THENA 1, was modified by replacing both exo-methylene protons with deuterium atoms. The modified CDA, THENA-d(2) 2, could be used to assign the absolute configuration of chiral secondary alcohols with good reliability. Compared with THENA, the multiplicity of the methylene proton signals in the H-1 NMR spectra of THENA-d(2) derivatives is less complicated and the new CDA thus offers simpler NMR spectra for data interpretation. (C) 2019 Elsevier Ltd. All rights reserved.
