Ramkhamhaeng University; Chiang Mai University; National Science & Technology Development Agency - Thailand; National Center Genetic Engineering & Biotechnology (BIOTEC); Khon Kaen University
Type
Article
Source Title
CHEMICAL & PHARMACEUTICAL BULLETIN
Year
2005
Volume
53
Issue
10
Page
1327-1329
Open Access
Bronze
Publisher
PHARMACEUTICAL SOC JAPAN
DOI
10.1248/cpb.53.1327
Format
PDF
Abstract
From the twigs of Scleropyrum wallichianum, a new unsaturated carboxylic acid, scleropyric acid (1), two 14 new esters, beta-sitosteryl-3-O-scleropyrate (2) and stigmasteryl-3-O-scleropyrate (3), and two well-known sterols, beta-sitosterol (4) and stigmasterol (5), were isolated and characterized using spectroscopic methods. Compound 1 exhibited antimycobacterial activity with an MIC value of 25 mu g/ml and showed antiplasmodial activity with an IC50 value of 7.2 mu g/ml. Compounds 2 and 3 were inactive in both assays.
