Mahidol University; National Science & Technology Development Agency - Thailand; National Center Genetic Engineering & Biotechnology (BIOTEC); Mahidol University; Mahidol University; Ministry of Public Health - Thailand
Type
Article
Source Title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN
0009-2363
Year
2005
Volume
53
Issue
2
Page
241-243
Open Access
Bronze
Publisher
PHARMACEUTICAL SOC JAPAN
DOI
10.1248/cpb.53.241
Format
PDF
Abstract
A new daphnane diterpenoid, rediocide F (1), was isolated together with three known compounds, rediocides A (2), C (3) and E (4), from the hexane extract of Trigonostemon reidioides roots by bioassay-guided fractionation for acaricidal activity on Dermatophagoides pteronyssinus, Thai common house dust mite. The structure of rediocide F (1) was established as the demethyl analog of rediocide C (3) on the basis of spectral analysis. Compounds 1-4 exhibited potent activity against D. pteronyssinus with respective LC50 values of 2.53, 0.78, 5.59 and 0.92 mug/cm(2).
